Migraine
Adult: Each tablet containing paracetamol 500 mg and metoclopramide 5 mg: Initially, 2 tablets at first warning of an attack. May repeat doses at 4 hrly intervals. Max: 6 tablets/24 hours.
Chỉ định và Liều dùng
Oral
Migraine Adult: Each tablet containing paracetamol 500 mg and metoclopramide 5 mg: Initially, 2 tablets at first warning of an attack. May repeat doses at 4 hrly intervals. Max: 6 tablets/24 hours.
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Chống chỉ định
Lactation. Children <12 yr.
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Thận trọng
Porphyria, epilepsy, parkinsonism, history of depression, pregnancy. Renal or hepatic impairment. May impair ability to drive or operate machinery. Risk of acute hypersensitivity reactions in patients with phaeochromocytoma. Exclude the possibility of an underlying disorder if patient has persistent vomiting.
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Tác dụng không mong muốn
Nausea, allergic reactions, skin rashes, acute renal tubular necrosis. Constipation or diarrhoea; drowsiness, headache, depression, lassitude, extrapyramidal reactions (especially if combined with phenothiazines); galactorrhoea; parkinsonism; neuroleptic malignant syndrome; tardive dyskinesia.
Potentially Fatal: Paracetamol: Very rare, blood dyscrasias (e.g. thrombocytopenia, leucopenia, neutropenia, agranulocytosis); liver damage. Metoclopramide: Very rarely, hypertensive crisis in patients with pheochromocytoma. Cardiac conduction disorders (IV admin). |
Quá liều
Overdose may cause damage to the liver. May be treated by gastric lavage with supportive measures. IV admin of N-acetylcysteine or oral methionine given within 10 hr of paracetamol overdosage may exert a protective effect on the liver.
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Tương tác
Action of metoclopramide may be antagonised by anticholinergics and opioid analgesics. Metoclopramide may affect the absorption of orally administered drugs when given together.
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Tương tác với thức ăn
Decreased rate of absorption with food.
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Tác dụng
Description:
Mechanism of Action: Metoclopramide is a dopamine antagonist, which binds to D2 receptors in the central and peripheral nervous system. It has anticholinesterase and antiemetic effects. Paracetamol is a centrally and peripherally acting non-opioid analgesic and antipyretic. |
Phân loại MIMS
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